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Association details:
| Biomarker: | NF1 deletion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | CI-1040 (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Response and Resistance to MEK Inhibition in Leukaemias Initiated by Hyperactive Ras
Excerpt:
Here we show that MEK inhibitors are ineffective in MPD, but induce objective regression of many Nf1-deficient AMLs...Mice with AML blasts in the peripheral blood were assigned to treatment with either vehicle (n = 11) or CI-1040 (n = 12)...recipients of Mx1-Cre, Nf1flox/flox AMLs invariably died with recurrent leukaemia despite ongoing treatment…
DOI:
10.1038/nature08279
