^
Association details:
| Biomarker: | NEK11 underexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Downregulation of NEK11 is associated with drug resistance in ovarian cancer
Excerpt:
...that the NEK11 mRNA was significantly downregulated in 586 cases of ovarian serous cystadenocarcinomas and cisplatin-resistant A2780 ovarian cancer cells….the first report of the association of NEK11 with drug resistance in cancer…
Secondary therapy:
tamoxifen + goserelin acetate
DOI:
10.3892/ijo.2014.2503