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Association details:
| Biomarker: | NECTIN4 overexpression |
|---|---|
| Cancer: | Triple Negative Breast Cancer |
| Drug: | 9MW2821 (Microtubule inhibitor, Nectin-4-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Published date:
08/01/2023
Excerpt:
The 9MW2821 conjugate exhibited substantial cytotoxicity in cell lines with high nectin-4 expression but was less effective toward medium and low nectin-4–expressing cell lines....Four typical triple-negative breast cancers with different nectin-4 expression were also treated with three injections of 3 mg/kg 9MW2821 weekly....The 9MW2821 conjugate produced rapid tumor regression and long-lasting tumor suppression in nectin-4 high-expression PDX models.
DOI:
https://doi.org/10.1158/1535-7163.MCT-22-0743
