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Association details:
| Biomarker: | NCOR2 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | epirubicin (Topoisomerase II inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2
Published date:
02/26/2020
Excerpt:
...we identified BQ323636.1 (BQ), a novel splice variant of nuclear co-repressor NCOR2...BQ was overexpressed in epirubicin-resistant cells and demonstrated that BQ overexpression could reduce the levels of epirubicin-induced ROS and confer epirubicin resistance. In vivo analysis using tissue microarray of primary breast cancer showed direct correlation between BQ expression and chemoresistance.
DOI:
10.3390/cancers12030533
