^
Association details:
Biomarker:MYD88 mutation
Cancer:Lymphoma
Drug:Imbruvica (ibrutinib) (BTK inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Dasatinib In Waldenström Macroglobulinemia

Excerpt:
...- Known tumor expression of mutated MYD88 performed by a CLIA certified laboratory....
Trial ID:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

The outcome of ibrutinib-based regimens in relapsed/refractory central nervous system lymphoma and the potential impact of genomic variants

Published date:
03/07/2023
Excerpt:
We aimed to explore the efficacy of ibrutinib in treating r/r CNSL patients, and whether genomic variants impact treatment outcomes….The PCNSL patients harboring gene mutations in PIM1, MYD88 and CD79B, and the proximal BCR and nuclear factor kappa B (NF-κB) pathways responded to ibrutinib.
DOI:
10.17219/acem/159288