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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Identification of a New Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia and Studies on Its Mechanism of Action

Published date:
11/06/2019
Excerpt:
A higher degree of apoptosis was also observed in the combination treatment as compared to a single drug. Immunoblot analysis revealed cleavage of PARP1 and lower levels of c-Myc and MCL1 expression in the presence of both ABT-199 and BI-6727.
DOI:
10.1182/blood-2019-129823