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Association details:
| Biomarker: | MYC overexpression |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | MRT-2359 (GSPT1 degrader) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
3929 / 3 - Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction
Published date:
03/09/2022
Excerpt:
...oral administration of MRT-2359 in high N-Myc NSCLC xenografts and PDXs led to complete intratumoral GSPT1 degradation and concomitant decrease in N-Myc protein levels, resulting in tumor regression.
