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Association details:
| Biomarker: | MYC overexpression |
|---|---|
| Cancer: | Lymphoma |
| Drug: | brusatol (NRF2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Flavonoid Brusatol Induces Apoptosis in Aggressive Lymphoma Cells and Exhibits Synergistic Effect with Venetoclax
Published date:
11/03/2022
Excerpt:
Seven cell lines (BL2, Jurkat, Karpas422, Raji, RI-1, SuDHL4 and U2932) representing different types of aggressive lymphomas...were treated with increasing concentrations of Brusatol...the protein expression profile of untreated cells indicates that cell lines with higher Myc-levels are more sensitive to Brusatol treatment....Our data indicate that Brusatol is able to efficiently induce cell death in aggressive lymphoma cells by reducing the expression of pro-survival proteins. Interestingly, cells with higher Myc-levels were especially sensitive to this flavonoid.
DOI:
https://doi.org/10.1182/blood-2022-166678
Source:
Title:
BRUSATOL INDUCES APOPTOSIS IN AGGRESSIVE LYMPHOMA CELLS IN VITRO AND SYNERGIZES WITH VENETOCLAX
Published date:
05/12/2022
Excerpt:
Seven cell lines (BL2, Jurkat, Karpas422, Raji, RI-1, SuDHL4 and U2932) representing different types of aggressive lymphomas...were treated with increasing concentrations of Brusatol...the protein expression profile of untreated cells indicates that cell lines with higher Myc-levels are more sensitive to Brusatol treatment....Our data indicate that Brusatol is able to efficiently induce cell death in aggressive lymphoma cells by reducing the expression of pro-survival proteins. Interestingly, cells with higher Myc-levels were especially sensitive to this flavonoid.
