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    Association details:
    Biomarker:MYC expression
    Cancer:Acute Myelogenous Leukemia
    Drug:inobrodib (CCS1477) (CBP inhibitor, EP300 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ASH 2019
    Title:

    CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma

    Published date:
    11/06/2019
    Excerpt:
    In the MOLM-16 (AML) model, CCS1477 administered daily by oral gavage (10mg/kg) demonstrated superior tumour growth inhibition by comparison with azacitidine or cytarabine. There was also a significant combination benefit of CCS1477 when administered with these two agents in this model.
    DOI:
    https://doi.org/10.1182/blood-2019-124707