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Association details:
| Biomarker: | MUS81 overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | SRA515 (BET inhibitor, BRD4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer
Published date:
05/29/2019
Excerpt:
As expected, AZD5153 treatment significantly reduced the migration of gastric cancer cells overexpressing Mus81 in vitro and in vivo Collectively...Importantly, we demonstrate that the BRD4 inhibitor AZD5153 can potentially be used as an effective antimetastasis drug because of its effect on Mus81.
DOI:
10.1158/1535-7163.MCT-18-0833
