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    Association details:
    Biomarker:MUC20 underexpression
    Cancer:Mantle Cell Lymphoma
    Drug:carfilzomib (Proteasome inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    J Cell Mol Med
    Title:

    Mucin 20 modulates proteasome capacity through c-Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma

    Published date:
    10/14/2021
    Excerpt:
    Carfilzomib-resistant (CR) MCL cell lines and primary samples were used for both in vitro and in vivo experiments to identify gene expression and explore their related signalling pathways. We first identified mucin 20 (MUC20) suppression in carfilzomib-resistant MCL models.
    DOI:
    10.1111/jcmm.16953