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Association details:
| Biomarker: | MUC16 overexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | ubamatamab (REGN4018) (CD3 agonist, MUC16 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer
Published date:
06/19/2020
Excerpt:
Moreover, in a genetically engineered immunocompetent mouse expressing human CD3 and human MUC16 [humanized target (HuT) mice], REGN4018 inhibited growth of murine tumors expressing human MUC16, and combination with an anti-PD-1 antibody enhanced this efficacy.
DOI:
10.1126/scitranslmed.aau7534
