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Association details:
Biomarker:MUC16 mutation
Cancer:HER2 Positive Breast Cancer
Drug:LZM-005 (HER2 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Phase I study of LZM005 in patients with HER2-positive metastatic breast cancer

Published date:
12/27/2022
Excerpt:
Here we report a phase I study that evaluated the safety, activity, and biomarkers of LZM005, a HER2 antibody, used as a monotherapy or in combination with trastuzumab plus docetaxel in patients with HER2-positive MBC....With regard to the PFS impact of genomic alterations, we found that KMT2B, MUC16, and KIR3DL2 were associated with PFS in the univariate Cox model.patients with KMT2B mutations had a longer progression-free interval (NR vs. 5.67 months, HR 0.2, p = 0.045) than their non-alters while patients with MUC16 (5.63 months vs. 11.10 months, HR 3.84, p = 0.035) or KIR3DL2 (5.67 months vs. 13.17 months, HR 4.0, p = 0.033) mutations showed faster progression than their counterparts.
DOI:
https://doi.org/10.1038/s41523-022-00501-2