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Association details:
| Biomarker: | MUC1 expression |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug Class: | MUC1 inhibitor |
| Direction: | Sensitive |
Evidence:
Title:
A novel humanized MUC1 antibody–drug conjugate for the treatment of trastuzumab-resistant breast cancer
Published date:
09/29/2021
Excerpt:
...an antibody-drug conjugate (ADC) was generated by conjugating HzMUC1 with monomethyl auristatin (MMAE), and the efficacy of HzMUC1-MMAE on the MUC1-positive HER2+ breast cancer in vitro and in 'Xenograft' model was tested....Results from colony formation assay and flow cytometry demonstrated that HzMUC1-MMAE significantly inhibited cell growth by inducing G2/M cell cycle arrest and apoptosis in trastuzumab-resistant HER2-positive breast cancer cells.
DOI:
10.1093/abbs/gmab141
