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Association details:
| Biomarker: | MTOR F2108L |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | Opsiria (sirolimus) (mTOR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
Excerpt:
Dose-dependent cell growth inhibition of the MDA-MB-468 cells expressing GFP, WT mTOR or different mTOR variants (A2034V, F2108L and M2327I) upon rapamycin or AZD8055 treatment
DOI:
10.1038/nature17963
