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Association details:
| Biomarker: | MTOR A2034V |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | RapaLink-1 (mTOR inhibitor, mTORC1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
Published date:
06/09/2016
Excerpt:
Mouse xenografts of MCF-7 cells expressing the RR1 mutant A2034V mTOR showed significantly less sensitivity to rapamycin yet maintained full sensitivity to AZD8055 and RapaLink-1 treatment.
DOI:
10.1038/nature17963
