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Association details:
| Biomarker: | MTA2 expression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | Lynparza (olaparib) (PARP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress
Published date:
07/17/2021
Excerpt:
...we analyzed proteomic profiling of 12 GC cell lines. MTA2 was identified to confer sensitivity to olaparib by aggravating olaparib-induced replication stress in cancer cells....results confirmed the speculation that MTA2 accelerates olaparib-induced DNA damage and thus increases the sensitivity of GC cells to olaparib.
DOI:
10.1016/j.tranon.2021.101167