^
Association details:
| Biomarker: | MSLN overexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | HK013 (CD137 agonist, Mesothelin inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
6338 / 14 - Development of a novel MSLN×4-1BB bispecific antibody
Published date:
03/15/2023
Excerpt:
HK013-G1, a MSLN×4-1BB bsAb with human IgG1 Fc fragment prevents tumor development by killing tumor cells directly via effector functions mediated by NK and cytotoxic T cells. These results show that this bsAb has the potential to develop into a new clinical therapy for cancer types with high-level MSLN expression.
