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Association details:
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Phase I Dose Escalation Study of BAY94-9343 Given by Intravenous Infusion Every 3 Weeks in Japanese Subjects With Advanced Malignancies

Excerpt:
...Tumor response based on RECIST (Response Evaluation Criteria in Solid Tumors)`Level of mesothelin expression using IHC (Immunohistochemistry) staining for the tumor tissue obtained from fresh or archival tumor tissue`Plasma levels of soluble mesothelin`Immunogenicity evaluation based on anti-BAY94-9343 antibody count...
Trial ID:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Phase 1b Multi-indication Study of Anetumab Ravtansine in Mesothelin Expressing Advanced Solid Tumors

Excerpt:
...- Availability of tumor tissue for mesothelin expression testing and for further biomarker analysis...
Trial ID:
More C2 evidence
Evidence Level:
Sensitive: C3 – Early Trials
Title:

First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody–Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors

Excerpt:
Among 148 patients with mesothelioma or ovarian, pancreatic, non–small-cell lung, and breast cancers, 1 had a complete response, 11 had partial responses, and 66 had stable disease….Anetumab ravtansine exhibited a manageable safety and favorable pharmacokinetic profile with encouraging preliminary antitumor activity in heavily pretreated patients with mesothelin-expressing solid tumors.
DOI:
10.1200/JCO.19.02085
Trial ID: