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Association details:
| Biomarker: | MRE11A mutation |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | Talzenna (talazoparib) (PARP inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro
Excerpt:
One endometrial cell line showed a markedly reduced MRE11 expression due to a homozygous poly(T) mutation of MRE11, thereby exhibiting an increased sensitivity to BMN673. MRE11 depletion sensitizes MRE11 expressing EC cell lines to the treatment with BMN673.
DOI:
10.1371/journal.pone.0100041
