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Association details:
| Biomarker: | MRC2 overexpression |
|---|---|
| Cancer: | Solid Tumor |
| Drug Class: | PD1 inhibitor |
| Direction: | Resistant |
Evidence:
Source:
Title:
Cancer-associated fibroblasts suppress CD8+ T cell infiltration and confer resistance to immune checkpoint blockade.
Published date:
06/24/2022
Excerpt:
Clinically, in a trial of melanoma patients, high MRC2 mRNA levels in tumors was associated with a poor response to αPD-1 therapy, highlighting the potential benefits of therapeutically targeting a specific CAF subpopulation in breast and other CAF-rich cancers to improve clinical responses to immunotherapy.
DOI:
10.1158/0008-5472.can-21-4141