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Association details:
| Biomarker: | MPZL3 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | Irene (pyrotinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A systemic pan-cancer analysis of MPZL3 as a potential prognostic biomarker and its correlation with immune infiltration and drug sensitivity in breast cancer
Published date:
07/29/2022
Excerpt:
Cell proliferation and drug sensitivity tests were applied to analyze the biological role of MPZL3 and drug sensitivities in breast cancer....Similarly, MDA-MB-231 cells overexpressing the MPZL3 gene were less sensitive to paclitaxel. Conversely, SKBR3 cells overexpressing the MPZL3 gene were more sensitive to pyrotinib.
DOI:
10.3389/fonc.2022.901728
