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Association details:
| Biomarker: | MMP9 overexpression |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MMP9 Expression Correlates With Cisplatin Resistance in Small Cell Lung Cancer Patients
Published date:
04/01/2022
Excerpt:
Multivariate results showed that MMP-High could be used as an independent predictor of the prognosis of SCLC after cisplatin treatment (HR = 0.216, p = 0.00153; HR = 0.352; p = 0.0199)….The KM curve shows that MMP9-High is related to significantly prolonged OS in patients with SCLC...In this study, we identified that MMP9-High could be potentially considered a novel biomarker used to ascertain the improved prognosis of SCLC patients after cisplatin treatment.
DOI:
10.3389/fphar.2022.868203