We conducted a retrospective study, which included patients diagnosed with NSCLC in our hospital from Jul-15 to Jan-21 and treated with immunotherapy...Note that in the group of MLL2 mutated, PFS was 8.6 months (CI: 1.5-15.8) vs 13.3 months in the MLL2 wild-type group (CI, not reached). This data could indicate a better response to immunotherapy in this subgroup.