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    Association details:
    Biomarker:MIR497HG deletion
    Cancer:Estrogen Receptor Positive Breast Cancer
    Drug:tamoxifen (Estrogen receptor antagonist)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Adv Sci (Weinh)
    Title:

    MIR497HG-Derived miR-195 and miR-497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer

    Published date:
    02/23/2023
    Excerpt:
    The results indicate that MIR497HG deficiency induces breast cancer progression and tamoxifen resistance...The findings reveal that ZEB1-induced MIR497HG depletion contributes to breast cancer progression and tamoxifen resistance through PI3K-AKT signaling. MIR497HG can be used as a biomarker for predicting tamoxifen sensitivity in patients with ER+ breast cancer.
    DOI:
    10.1002/advs.202204819