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Association details:
| Biomarker: | miR-638 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
miR-638 Serves as a Biomarker of 5-Fluorouracil Sensitivity to Neoadjuvant Chemotherapy in Breast Cancer
Published date:
06/03/2022
Excerpt:
The MiniPDX™ model showed that MDA-MB-231 cells overexpressing miR-638 were more susceptible to 5-FU treatment in vivo....Overall, our findings uncovered a novel role for miR-638 in the regulation of 5-FU chemosensitivity in BC patients. miR-638 may serve as a potential biomarker for NAC response in patients with BC.
DOI:
https://doi.org/10.4048/jbc.2022.25.e24