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    Association details:
    Biomarker:miR-518d-5p overexpression
    Cancer:Hepatocellular Cancer
    Drug:sorafenib (Multi-tyrosine kinase inhibitor, pan-RAF inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Cell Death Dis
    Title:

    Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

    Published date:
    05/28/2021
    Excerpt:
    miR-518d-5p overexpression counteracted the effect of sorafenib on tumor growth compared to miR-Control tumors...xenograft mouse model provided evidence for an in vivo role of miR-518d-5p in sorafenib drug resistance…
    DOI:
    https://doi.org/10.1038/s41419-021-03827-0