The overexpression of miR-200c-3p or miR-485-5p aggravated DDP-mediated suppressive effect on tumor growth in vivo....DDP alone suppressed the growth of xenograft tumors, and tumor growth was further restrained with the overexpression of miR-200c-3p or miR-485-5p (Figure 9(a),(e)). Tumor weight was reduced with DDP treatment, and the overexpression of miR-200c-3p or miR-485-5p further reduced tumor weight (Figure 9(b),(f))....These results demonstrated that miR-200c-3p or miR-485-5p overexpression elevated the DDP sensitivity of xenograft tumors in vivo...our study found that miR-200c-3p and miR-485-5p suppressed NSCLC development and elevated the DDP sensitivity of NSCLC cells partly through targeting RRM2.