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Association details:
| Biomarker: | miR-200b underexpression + miR-103a underexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Predictive and Prognostic Value of an MicroRNA Signature for Gastric Carcinoma Undergoing Adjuvant Chemotherapy
Published date:
11/12/2021
Excerpt:
We then assessed the responses of these GC cells to 5-Fluorouracil treatment under different concentrations. The result showed that the cell lines with higher expression of miR-199b/miR-152 (while lower expression of miR-200b/miR-103a) exhibited more resistance to fluorouracil than the other cell lines (Fig. 4C).
DOI:
10.1089/dna.2021.0377
