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Association details:
| Biomarker: | miR-199a-5p expression |
|---|---|
| Cancer: | Colon Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1
Excerpt:
Among the upregulated miRNAs, we focused on miR-199a-5p and miR-375. We report that their enforced expression promotes CTX resistance, whereas their silencing sensitizes to the same drug….study proposes miR-199a-5p and miR-375 as contributors to CTX resistance in colon cancer...
DOI:
https://doi.org/10.1517/14728222.2015.1057569
