Em-Myc lymphoma cells overexpressing miR-17 92 were significantly more sensitive than control cells when treated with either phenformin or IM156....These data indicate that elevated miR-17 92 enhances the sensitivity of lymphoma cells to biguanide treatments and that Myc and miR-17 92 synergize to increase sensitivity to biguanide treatment...phenformin and IM156 can act as sin gle agents to extend the survival of mice bearing tumors with elevated miR-17 92 expression, with elevated miR-17 92 expression functioning as a predictor of sensitivity to biguanides.