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Association details:
| Biomarker: | miR-17-HG deletion + MYC positive |
|---|---|
| Cancer: | Lymphoma |
| Drug: | phenformin (mTOR inhibitor, AMPK activator) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Repression of LKB1 by miR-17~92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Published date:
05/19/2020
Excerpt:
Em-Myc lymphoma cells deleted for miR-17 92 (D/D) were more resistant to phenformin treatment…
DOI:
https://doi.org/10.1016/j.xcrm.2020.100014
