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    Association details:
    Biomarker:miR-17-HG deletion + MYC positive
    Cancer:Lymphoma
    Drug:phenformin (mTOR inhibitor, AMPK activator)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    Source:
    Cell Reports Medicine
    Title:

    Repression of LKB1 by miR-17~92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment

    Published date:
    05/19/2020
    Excerpt:
    Em-Myc lymphoma cells deleted for miR-17 92 (D/D) were more resistant to phenformin treatment…
    DOI:
    https://doi.org/10.1016/j.xcrm.2020.100014