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Association details:
| Biomarker: | miR-125b-2 underexpression |
|---|---|
| Cancer: | HER2 Positive Breast Cancer |
| Drug: | letrozole (Aromatase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
ASSOCIATION OF miRNA EXPRESSION PATTERN WITH OUTCOME OF LETROZOLE THERAPY IN BREAST CANCER PATIENTS
Published date:
10/11/2023
Excerpt:
Most HER2/neu+ BC patients had low levels of miR-155 and miR-221 expression in tumor biopsy specimens. Tumors that responded well to letrozole exhibited lower levels of miR-125b-2 and miR-221 compared to non-responsive tumors….miR-125b-2, -155, and -221 expression can predict resistance to the letrozole treatment of BC.
DOI:
https://doi.org/10.15407/exp-oncology.2023.02.180
