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Association details:
| Biomarker: | MET positive |
|---|---|
| Cancer: | Gastric Cancer |
| Drug Class: | c-MET-targeted CAR-T immunotherapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer
Published date:
11/16/2021
Excerpt:
In an in vivo xenograft assay with NSG bearing MKN-45, a c-Met positive GC cell line, c-Met CAR T cells effectively inhibited the tumor growth of MKN-45. Our results show that the c-Met CAR T cell therapy can be effective on GC.
DOI:
10.3390/cancers13225738
