^
    Back
    Association details:
    Biomarker:MET positive
    Cancer:Gastric Cancer
    Drug Class:c-MET-targeted CAR-T immunotherapy
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Cancers (Basel)
    Title:

    c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer

    Published date:
    11/16/2021
    Excerpt:
    In an in vivo xenograft assay with NSG bearing MKN-45, a c-Met positive GC cell line, c-Met CAR T cells effectively inhibited the tumor growth of MKN-45. Our results show that the c-Met CAR T cell therapy can be effective on GC.
    DOI:
    10.3390/cancers13225738