^
Association details:
Biomarker:MET positive
Cancer:Gastric Cancer
Drug Class:c-MET-targeted CAR-T immunotherapy
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

c-Met-Specific Chimeric Antigen Receptor T Cells Demonstrate Anti-Tumor Effect in c-Met Positive Gastric Cancer

Published date:
11/16/2021
Excerpt:
In an in vivo xenograft assay with NSG bearing MKN-45, a c-Met positive GC cell line, c-Met CAR T cells effectively inhibited the tumor growth of MKN-45. Our results show that the c-Met CAR T cell therapy can be effective on GC.
DOI:
10.3390/cancers13225738