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Association details:
| Biomarker: | MET overexpression |
|---|---|
| Cancer: | Pancreatic Cancer |
| Drug: | SHR-A1403 (Microtubule inhibitor, c-MET-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer
Excerpt:
The c-MET expression levels in pancreatic cancer cell lines were significantly increased compared to the expression in HPNE cells, particularly in Aspc-1 cells...SHR-A1403 potently inhibited proliferation of Aspc-1 cells, with an IC50 value of 281.3 ng/mL...
DOI:
https://doi.org/10.3389/fonc.2021.634881
