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Association details:
| Biomarker: | MET overexpression |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | tivantinib (ARQ 197) (c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Tivantinib inhibits the VEGF signaling pathway and induces apoptosis in gastric cancer cells with c-MET or VEGFA amplification
Published date:
05/04/2020
Excerpt:
We found that tivantinib has anti-cancer activity not only in GC cells overexpressing c-Met but also in non-c-Met GC cells by inhibition of the VEGF signaling pathway.
DOI:
10.1007/s10637-020-00940-3
