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    Association details:
    Biomarker:MET overexpression + SYK overexpression
    Cancer:Non Small Cell Lung Cancer
    Drug:Haiyitan (gumarontinib) (c-MET inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Signal Transduct Target Ther
    Title:

    SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer

    Published date:
    05/15/2023
    Excerpt:
    Mice were treated with c-Meti (capmatinib/INCB28060 or SCC244)...2 of the 4 c-Met-overexpressing PDX models without MET amplification had high SYK expression and responded well to c-Metis…
    DOI:
    https://doi.org/10.1038/s41392-023-01403-w