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Association details:
| Biomarker: | MET expression |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | MYTX-011 (Microtubule inhibitor, c-MET-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 5000: MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors
Published date:
04/04/2023
Excerpt:
MYTX-011 showed markedly higher (>3 fold) internalization in cMET+ tumor cells and broader, more potent cytotoxicity across a large panel of cMET+ cancer cell lines in vitro...Together, these findings highlight the potential of MYTX-011 as a therapeutic candidate for treating a broader range of cMET+ malignancies than other cMET-ADCs.
DOI:
10.1158/1538-7445.AM2023-5000
