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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Preclinical Study of a Biparatopic METxMET Antibody-Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC

Published date:
01/04/2023
Excerpt:
REGN5093-M114 exhibited significant antitumor efficacy compared with MET TKI or unconjugated METxMET biparatopic antibody (REGN5093). Cell surface MET expression had the most predictive power in determining the efficacy of REGN5093-M114.
DOI:
10.1158/1078-0432.CCR-22-2180