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Association details:
Biomarker:
MET expression
Cancer:
Non Small Cell Lung Cancer
Drug:
Rozlytrek (entrectinib)
(
ALK inhibitor
,
TrkB receptor inhibitor
,
TrkC kinase inhibitor
,
TrkA receptor inhibitor
,
ROS1 inhibitor
,
JAK2 inhibitor
,
TNK2 inhibitor
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Source:
AACR-II 2020
Title:
MET mediates entrectinib resistance in ROS1 gene fusion positiveNSCLC
Published date:
05/15/2020
Excerpt:
CUTO38 is resistant to entrectinib in vitro and displays elevated MET expression…
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