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Association details:
| Biomarker: | MET expression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | HRA00129-C004 (Topoisomerase I inhibitor, c-MET-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
HRA00129-C004, a Novel c-Met ADC with Promising Preclinical Anti-tumor Activity and Expanded Therapeutic Window
Published date:
08/08/2023
Excerpt:
HRA00129-C004 significantly inhibited the growth of c-Met expressing lung cancer, GC and CRC cell lines with the IC50 in sub nanomolar range. HRA00129-C004 was able to kill both EBC-1 (c-Met+) and SW480 (c-Met-) cells when co-cultured, which is speculated to be a critical factor of robust anti-tumor efficacy overcoming the heterogeneity of solid tumors. Treatment with 1, 3, 10 mg/kg HRA00129-C004 demonstrated dose-dependent anti-tumor efficacy in GC and CRC PDX models, with tumor growth inhibition rate (TGI%) between 66% and 107%. In NCI-H441 lung cancer CDX models, treatment with 1, 3, 10 mg/kg HRA00129-C004 could significantly inhibit the tumor growth (TGI%=106%, 107% and 109%), respectively.
