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Association details:
| Biomarker: | MET exon 14 mutation |
|---|---|
| Cancer: | Gastric Cancer |
| Drug: | S95027 (c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Sym015: A Highly Efficacious Antibody Mixture against MET-Amplified Tumors
Published date:
07/05/2017
Excerpt:
...tested Sym015 in patient- and cell line-derived xenograft models with high MET expression and/or MET exon 14 skipping alterations, and in models harboring MET amplification as a mechanism of resistance to EGFR-targeting agents.Sym015 effectively inhibited tumor growth in all these models and was superior to an analogue of emibetuzumab, a monoclonal IgG4 antibody against MET currently in clinical development.
DOI:
10.1158/1078-0432.CCR-17-0782.
