IC50 values of JNJ3887605 and SGX523 for inhibition of cell growth were 0.02 to 0.05 μM and 0.06 to 0.07 μM, respectively, for cells positive for MET amplification...An annexin V binding assay revealed that both MET-TKIs induced a substantial level of apoptosis in MET amplification–positive cells but were largely without effect in cell lines without MET amplificatin...gastric cancer cells with MET amplification are predominantly dependent on MET signaling for their growth and survival and are therefore rendered hypersensitive to MET-TKIs.