In this case, we present a metastatic cholangiocarcinoma patient with high-level MET gene amplification for whom capmatinib, a tyrosine kinase inhibitor with activity against c-MET, provided a partial response after cessation of chemotherapy….He was started on capmatinib 400 mg twice daily and tolerated this dose well. Interval imaging 3 months later showed a partial response with decrease in size of the liver mass to 6.0 cm x 3.9 cm x 7.1 cm (Figure 2c).