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Association details:
| Biomarker: | MERTK expression |
|---|---|
| Cancer: | Melanoma |
| Drug: | RGX-019 (MERTK-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
/ 17 - In vivo efficacy and safety of RGX-019, a MerTK targeting monoclonal antibody
Published date:
05/15/2020
Excerpt:
Immunohistochemical analysis of human tumor samples revealed MerTK expression in a large fraction (>50%) of breast cancer, melanoma and non-small cell lung cancers….In in vivo xenograft models we demonstrate that RGX-019 suppressed tumor progression by >70%. Anti-tumor activity was associated with near complete depletion of MerTK from the surface of cancer cells in vivo.
