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Association details:
| Biomarker: | MDM4 amplification |
|---|---|
| Cancer: | Gastric Adenocarcinoma |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
2375 - Comprehensive analysis of immunotherapy-related biomarkers in Chinese patients with gastric adenocarcinoma
Published date:
03/10/2021
Excerpt:
...the biomarkers associated with hyperprogression (HP) to immune checkpoint inhibitors (ICIs) included 11q13 amp, MDM2/MDM4 amp, and CDKN2A/B gene loss, which were identified in 4%, 2% and 2% of patients, respectively.
