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    Association details:
    Biomarker:MDM2 overexpression
    Cancer:Acute Lymphocytic Leukemia
    Drug:MX69-114b (MDM2 protein degrader)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    AACR 2023
    Title:

    470 / 1 - A MDM2 degrader inhibits cell proliferation and growth of MDM2-overexpressing acute lymphoblastic leukemia in SCID mice

    Published date:
    03/15/2023
    Excerpt:
    MX69-114b exhibited significantly enhanced inhibitory and apoptotic effects on a group of MDM2-overexpressing ALL cell lines in vitro with IC50 values of 0.08-0.14 µM...