^
Association details:
| Biomarker: | MCL1 expression |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | APG-3526 (MCL1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Abstract 73: Development of APG-3526 as a novel and highly efficacious MCL-1 inhibitor
Published date:
05/15/2020
Excerpt:
...we have developed a novel and highly potent MCL-1 inhibitor, APG-3526, which displays clinically relevant pharmacokinetic properties and elicits potent antiproliferative and antitumor activities via disrupting MCL-1 complex and triggering caspase activation, especially in MCL-1 driven MM models.
DOI:
10.1158/1538-7445.AM2020-73
