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Association details:
| Biomarker: | MAP3K6 overexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | letrozole (Aromatase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade
Published date:
01/30/2021
Excerpt:
...a global proteomic analysis was conducted using the letrozole-sensitive (T47Darom cells) and letrozole-resistant cells (T47DaromLR cells)….MAP3K6 was up-regulated in the T47DaromLR cells by 3.2-fold (p<0.01) which was associated with a decrease in relapse-free survival among breast cancer patients (p=0.0019).
DOI:
10.21873/anticanres.14810