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Association details:
| Biomarker: | MAP2K1 P124S |
|---|---|
| Cancer: | Melanoma |
| Drug: | PLX4720 (BRAF inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
MEK1 mutations confer resistance to MEK and B-RAF inhibition
Excerpt:
Both MEK1(P124L) and MEK1(Q56P), which disrupts helix A, conferred cross-resistance to PLX4720, a selective B-RAF inhibitor in A375 cells.
DOI:
10.1073/pnas.0905833106
